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Biosystems Prealbumin Reagent

PRINCIPLE OF THE METHOD

Prealbumin, also known as transthyretin, in the sample precipitates in the presence of antihuman prealbumin antibodies. The light scattering of the antigen-antibody complexes is proportional to the prealbumin concentration and can be measured by turbidimetry1,2

COMPOSITION

A. Reagent 2 x 60 mL: Imidazole buffer 0.1 mol/L, goat anti-human PAB antibodies, sodium
azide 0.95 g/L, pH 7.5.

Biosystems Prealbumin Reagent

STORAGE

Store at 2-8ºC.
The Reagent is stable until the expiry date shown on the label when stored tightly closed and if contaminations are prevented during its use.

Indications of deterioration: Presence of particulate material, turbidity, absorbance of the blank
over 0.300 at 340 nm.

AUXILIARY REAGENT

− Protein Calibrators (BioSystems Cod. 31075). The set contains 5 different levels of prealbumin concentration and it should be used to prepare the calibration curve.

The calibrators are supplied ready to use.

Biosystems Prealbumin Reagent  SAMPLES

Serum or plasma collected by standard procedures (use heparin or EDTA as anticoagulants).
Serum or plasma prealbumin is stable for 6 months at 2-8°C.3

Biosystems Prealbumin Reagent

REFERENCE VALUES

Serum, adults4
: 20 – 40 mg/dL = 0.20 – 0.40 g/L.
This range is given for orientation only; each laboratory should establish its own reference
range.

CALIBRATION

It is recommended to use a serum based calibrator (Protein Calibrator, cod. 31075).
A calibration is recommended at least every 2 months, after reagent lot change or as required by
quality control procedures.

Biosystems Prealbumin Reagent

ASSAY PARAMETERS

These reagents may be used in several automatic analysers. Specific instructions for application
in many of them are available on request.
− Wavelength: 340 nm
− Temperature: 37ºC
− Analysis mode: end point

Biosystems Coagulation reagents include the main diagnostic tests and they are characterized by high stability and a good performance using low volume consumption.

These reagents can be performed in semiautomatic and automatic coagulation instruments, independently of the kind of clot detection method (optical and mechanic).

Biosystems Prealbumin Reagent

• Activated Partial Thromboplastin Time (APTT)
  • 61004APTT A
  • 61005APTT B (CaCl2)
• Coagulation Calibrators
  • 61006COAGULATION CALIBRATOR
• Coagulation Controls
  • 61007LEVEL I
  • 61008LEVEL II
• Fibrinogen Clauss
  • 61002FIBRINOGEN CLAUSS A
  • 61003FIBRINOGEN CLAUSS B (IMIDAZOL)
• Prothrombin Time (PT)
  • 61001PROTHROMBIN TIME
• Thrombin Time (TT)
  • 61000THROMBIN TIME